<International Circulation>:As an expert in vascular endothelial vascular study， how can we go about improving function?
《国际循环》：您作为一位在血管内皮研究领域的专家，请问怎样才能改善内皮功能？
Prof. Alvolio : Function is improved with exercise. Exercise seems to be related to aspects of blood flow. If there is increased flow， increased shear on the endothelial cells would result in the production of certain molecules. One of which that is important is nitrous oxide， which has essentially beneficial effects in terms of dilating the vessels， improving and increasing perfusions. With increased perfusions， there is increased oxygen delivery and cells become more functional. In the larger vessels， if the nitrous oxide affects the smooth muscles， it affects the smooth muscle stiffness. That will then affect aspects of blood pressure. These are closed loop situations. Improving endothelial function is an important factor， exercise seems to do it， anti-inflammatories seem to help. There area whole cascade of processes that are currently being interrogated.
Alvolio教授：运动会改善内皮功能。运动似乎和血流相关。如果血流增肌，作用于内皮细胞的剪切力就会增加，结果会增加一些活性分子的产生。在这些活性分子中很重要的就是一氧化氮，它最基本的益处就是扩张血管，增加和改善器官的灌注。灌注增加后，氧供也会增加，细胞的功能就会得到改善。在更大的血管中，如果一氧化氮作用于平滑肌，它就会影响平滑肌的弹性。这时就会影响血压。这些是环路效应。改善内皮细胞的功能是很重要的一方面，运动似乎能做到这一点，抗炎也似乎有益处。这一领域的全部级联过程目前正在研究中。
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