手机网
关键词
首页>>正文

NESTOR研究:长效吲达帕胺对微蛋白尿的作用——长效吲达帕胺对微蛋白尿的作用——NESTOR研究(长效钠崔离与依纳普利对伴有微蛋白尿的2型糖尿病高血压患者的研究)—主要试验原理与设计
[2006/12/15 0:00:00]
 全文(共1页)

Hopital Bichat, Paris, France. michel.marre@bch.ap-hop-paris.fr

 In type 2 diabetic hypertensive patients, microalbuminuria can be due to hypertension and/or diabetic nephropathy. Angiotensin-converting enzyme (ACE) inhibitors act preferentially on microalbuminuria due to diabetic nephropathy. The objective is to demonstrate the efficacy of a thiazide-like diuretic, indapamide sustained release (SR), at reducing microalbuminuria in hypertensive type 2 diabetic patients in comparison with an ACE inhibitor, enalapril. The study is an international multicentre, 12-month, randomized, double-blind, controlled, two parallel group study of type 2 diabetic patients with hypertension (140 mmHg < or = systolic blood pressure <180 mmHg and diastolic blood pressure <110 mmHg) and microalbuminuria. Intervention is after a 4-week placebo period, patients with microalbuminuria > or = 20 and < or = 200 microg/min are randomized to indapamide SR 1.5 mg or to enalapril 10 mg once a day for a one-year treatment period. An additional label treatment by amlodipine 5-10 mg (1st step) and atenolol 50-100 mg (2nd step) a day is permitted after 6 weeks of treatment based upon blood pressure response. The main outcome measures are microalbuminuria expressed as urinary albumin to creatinine ratio, albumin fractional clearance, and albumin excretion rate evaluated on overnight urine collections. Secondary criteria are supine and standing systolic, diastolic and mean blood pressure; and biological and clinical safety. This study will complete the knowledge of the efficacy of indapamide SR in hypertension and target organ damage and will provide valuable information on the management of type 2 diabetic hypertensives with microalbuminuria.




 
更多热点
更多   心血管   相关搜索
声明:登陆《国际循环》手机网不收业务信息费,只产生运营商收取的上网流量费。
返回顶端| About Us | 客服中心 |收藏本站
WapURL手机网址(wap.icirculation.com)