Eur Heart J. 2001 Jul;22(13):1119-27. Wilhelmsen L， Pyorala K， Wedel H， Cook T， Pedersen T， Kjekshus J. Institute of Heart and Lung Diseases， Goteborg University， Goteborg， Sweden.
AIMS: To analyse (1) the prognostic importance of clinical findings and lipids in patients with a previous myocardial infarction and (2) the relative and absolute benefit of simvastatin in patients at low， medium and high predicted risk.
METHODS: The 4S was a double-blind， randomized， clinical trial of long-term treatment with simvastatin or matching placebo in patients with myocardial infarction or angina pectoris， serum total cholesterol 5.5-8.0 mmol x l(-1)， and serum triglycerides