Diabetes Care. 2004 Jul;27(7):1735-40. Pyorala K， Ballantyne CM， Gumbiner B， Lee MW， Shah A， Davies MJ， Mitchel YB， Pedersen TR， Kjekshus J; Scandinavian Simvastatin Survival Study (4S). Department of Medicine， Kuopio University Hospital， Kuopio， Finland. kalevi.pyorala@uku.fi
OBJECTIVE: To assess the effect of simvastatin treatment on the risk of cardiovascular events in nondiabetic patients with coronary heart disease (CHD) with and without the metabolic syndrome， as defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP-III).
RESEARCH DESIGN AND METHODS: Subgroup analyses were performed on data from 3933 nondiabetic patients with clinically established CHD， serum total cholesterol level 5.5-8.0 mmol/l， and serum triglyceride level